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After installing the seemingly harmless Security Update for Windows SharePoint Services 3.0 x64(KB9834444) update on a SBS 2008 server, users complained the next day that they couldn't open CompanyWeb. They would receive the error "Cannot connect to the configuration database." In short, the fix was to re-run the Configuring Sharepoint Products and Technologies Wizard. As soon as we kicked that off we received the message that there were new files that needed to be updated so obviously something needed to get upgraded that the Windows Update process didn't handle. Seems like the kind of thing that should have received a pop-up of some sort during the Windows Update install.
At any rate, re-running the Configuring Sharepoint Products and Technologies Wizard in Administrative Tools fixed the issue.